Horizant® offers 2x greater bioavailability vs conventional gabapentin2
PHARMACOKINETICS >
Bioavailability
Horizant® was designed as an extended-release gabapentin formulation with enhanced absorption1,2
This may contribute to the difference in bioavailability of Horizant® compared with conventional gabapentin1,2
Bioavailability of Horizant® vs conventional gabapentin2,a,b
Horizant® bioavailability2
Fed state
74.5%
Conventional gabapentin bioavailability2
Fasted state
36.6%
aHorizant® 1200 mg (two 600 mg tablets, equivalent in total to 626 mg of conventional gabapentin) taken with food vs conventional gabapentin 600 mg taken without food. Data for fasted state are not available, as Horizant® Prescribing Information states that it should be taken with food.1,2
bThe molecular weight of Horizant® is ~2 times that of gabapentin: Two 600 mg doses of Horizant® contain ~626 mg of gabapentin.1,2
Horizant® is not interchangeable with other gabapentin products.1
The clinical significance of the PK data for Horizant® and gabapentin is unknown.
